Know When to Stop Blending
Proper blending is vital to assure batch uniformity and the integrity of drug products. It is important that the Active Pharmaceutical Ingredient (API), excipients, and lubricants in each batch are uniform and homogenous. A batch that is not fully blended can affect bioavailability in the end product and potentially harm the consumer.
timing and random sampling
The most common method used to determine BU is through the use of timing and random sampling. Traditionally, the blend is run for a certain amount of time with samples taken and run through an HPLC to confirm proper ratios.
Brimrose AOTF-NIR spectrometers are non-destructive test devices for determining BU. As opposed to traditional methods Brimrose spectrometers mount directly onto the blender taking lab quality measurements in real-time, and determines when blending is complete.
Successful implementation of an AOTF-NIR spectrometer results in:
Measurements are taken in line with no sample preparation
Samples are not destroyed during analysis
Reduce man hours spent on routine lab work
Save energy, time, and money from errors in production
Minimize rework and scrap
Why are you still in the Lab?
Acousto-Optic Tunable Filter (AOTF) Diagram
Brimrose AOTF-NIR Spectrometer Demo