Know When to Stop Blending



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proper blending

Proper blending is vital to assure batch uniformity and the integrity of drug products. It is important that the Active Pharmaceutical Ingredient (API), excipients, and lubricants in each batch are uniform and homogenous. A batch that is not fully blended can affect bioavailability in the end product and potentially harm the consumer.

Lab work

timing and random sampling

The most common method used to determine BU is through the use of timing and random sampling. Traditionally, the blend is run for a certain amount of time with samples taken and run through an HPLC to confirm proper ratios.

4080 on V Blender

why brimrose?

Brimrose AOTF-NIR spectrometers are non-destructive test devices for determining BU. As opposed to traditional methods Brimrose spectrometers mount directly onto the blender taking lab quality measurements in real-time, and determines when blending is complete.

Successful implementation of an AOTF-NIR spectrometer results in:

  • Measurements are taken in line with no sample preparation

  • Samples are not destroyed during analysis

  • Reduce man hours spent on routine lab work

  • Save energy, time, and money from errors in production

  • Minimize rework and scrap

Why are you still in the Lab?

AOTF Diagram

Acousto-Optic Tunable Filter (AOTF) Diagram


Brimrose AOTF-NIR Spectrometer Demo

Spectrometers for improving performance

solution Notes